Article

유산균 R&B Balance®의 대장염 억제 효과

안영태*, 이호용, 이정희, 김동현1, 허철성
Young-Tae Ahn*, Hoyong Lee, Jung-Hee Lee, Dong-Hyun Kim1, Chul-Sung Huh
Author Information & Copyright
㈜한국야쿠르트 R&BD
1경희대학교 약학대학
R & BD, Korea Yakult Co., Ltd., Youngin 446-901, Korea
1Department of Pharmaceutical Science, Kyung Hee University, Seoul 130-701, Korea
*Corresponding author: Young-Tae Ahn, R&BD, Korea Yakult Co., Ltd., Youngin 446-901, Korea. Tel: 82-70-7835-6037, Fax: 82-31-8005-7830, E-mail: ytahn@re.yakult.co.kr

Copyright © Korean Society for Lactic Acid Bacteria. All rights reserved. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published Online: Jun 30, 2019

Abstract

The anti-colitic effect of lactic acid bacteria mixture (R&B Balance®) consisting of Lactobacillus brevis HY7401, Lactobacillus helveticus HY7801 and Bifidobacterium longum HY8004 was investigated in dextran sulfate sodium (DSS)-induced colitic mice. Treatment with R&B Balance® reduced severe colitic symptoms, including colon shortening, myeloperoxidase (MPO) activity and malondialdehyde (MDA). The oral administration of R&B Balance® significantly reduced the activities of fecal chondroitinase and the fecal genotoxicity. Changes of fecal microflora in mice treated with DSS with or without R&B Balance® were assessed by terminal restriction fragment length polymorphism (T-RFLP). Cluster analysis of T-RFLP patterns demonstrated that microflora of DSS-induced colitic mice differed from that of normal mice and the oral administration of R&B Balance® could change the structure of gut microflora. These findings also suggest that R&B Balance® may improve colitis by inhibition of the production of harmful enzymes or toxic metabolites in intestine and influence the intestinal microbial diversity in DSS-induced colitic mice.

Keywords: anti-colitis; dextran sulfate sodium; lactic acid bacteria; R&B Balance®